What is Demyelination?
By: Naumann Cornett
Demyelination itself is damage done to the fatty covering, or substance that encases nerve endings. This results in diverse symptoms determined by the functions of the affected nerves. There are many factors that lead to demyelination, even though it is mainly genetics; additional factors such as infectious agents and autoimmune agents can cause this. Demyelination, in later life, is an element of many neurologic problems; it can result from damage to nerves or myelin due to local injury, ischemia, toxic agents, or metabolic difficulties.
A number of the symptoms of demyelination are clumsiness and visual disturbances; this can be anything from pain in the eye to partial loss of sight. There may also be cognitive disability; this can include issues with memory, attention, conceptualization, and problem solving. It can also cause neurological deficits like paralysis in the trunk area or one side on the body. These symptoms will vary depending on the disease.
Here is a List of Some Demyelination Symptoms:
Demyelination can have horrible affects in your daily life. It will take a powerful athlete that’s in great shape, to somebody that cannot take care of himself very quickly.
Treatment for chronic demyelination should begin during the time of diagnosis, the sooner treatment is began the less damage to the nerve axon. The most effect treatment, at this time, is the use of hormone steroids, by corticosteroid injections. Scientists are always doing research to find new methods to repair the myelin sheath.
There are research that show that a few specific antibodies can help with repairing the myelin sheath. There are also some new techniques to implant oligodendrocytes that are working in mice; but haven’t been tested on humans. This likely will not help somebody with MS since several areas are damaged, but for other diseases, this could be promising.
Remyelination is a vital stride for nerve regeneration and it is an important therapeutic objective. Lots of scientists hold hope that this will be realistic, making this an exciting study. There are encouraging leads in the stem cell research area and that remyelination can happen in the brain. Scientists are thinking that one of the two of those research areas will one day succeed in remyelinating damaged axons. It is just too soon and there are too many uncertainties to say they have been successful as of now.
It does not matter what disease you are suffering from; Multiple Sclerosis, Parkinson’s, or some sort of autoimmune issue – the pain and agony is the same. It is also extremely annoying to know that there is help so near, but still so far away. It’s hard for you to watch this happen to someone that you care about and even worse if it is happening to you.
Nevertheless, there’s hope, and you also must keep that in mind. Hold on to the concept that help can come at some point. Seek out those who can understand what you are going through. It will help to be with people who can empathize. You may find a support group in your area, or simply join one online. Just understand you’re not alone; your demyelination may have you feeling isolated – however, you really are not.
An example of hope is the gene therapy discussed at Sciencecodex.com , to quote:
The therapy, which has been successful in promoting remyelination in a mouse model of MS, is outlined in a paper published February 8 in The Journal of Neuroscience.
“We’ve developed a gene therapy to stimulate production of new oligodendrocytes from stem and progenitor cells—both of which can become more specialized cell types—that are resident in the adult central nervous system,” says Benjamin Deverman, a postdoctoral fellow in biology at Caltech and lead author of the paper. “In other words, we’re using the brain’s own progenitor cells as a way to boost repair.”
Us this link to read more on Gene Therapy to Boost Brain Repair for Demyelinating Diseases .
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